A five-level, 150,000-square-foot outpatient cancer center belonging to the University of Virginia's (UVA) health-care system.

Owner: Hoag Hospital Completion Date: August 2010 Program: A 244,000-square-foot acute care and orthopedic specialty hospital composed of a five-story patient bed tower that adjoins a three-level central atrium. The project is a renovation of the Irvine Regional Hospital and Medical Center, a 20-year-old community hospital that was taken over by the Hoag system. A new program, the Hoag Orthopedic Institute, has nine operating rooms on the second floor of the atrium building; it replaces a mother-baby facility, which was absorbed by Hoag Hospital Newport. The Irvine project also includes two additional operating rooms, an 11-bay emergency department, imaging and

In the late 1960s, Dr. Michael DeBakey performed some of the country’s first heart transplants at the Methodist Hospital in Houston.

A four-level, 46,500-square-foot cultural center in downtown Charlotte. Situated on a narrow 50-by-400-foot tract, the project includes galleries, classrooms, offices, and event space.

Steven Holl made his first sketches for the Knut Hamsun Center, in the municipality of Hamarøy, Norway, in 1994.

A single-story, 3,600-square-foot art gallery with offices, two galleries, a private viewing room, a preparator's area, and a flower garden that can accommodate sculptures.

For the hordes of tourists stuck in lines for the Colosseum or queuing up to enter the Sistine Chapel, Rome’s 2,000-year history acts as a powerful magnet.

A 1,700-square-foot museum devoted to pioneer neurosurgeon Dr. Harvey Cushing, located in a sub-basement of the Harvey Cushing/John Hay Whitney Medical Library at the Yale School of Medicine.